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Sepsis is a serious medical condition that can be life-threatening and requires prompt and accurate intervention. One of the crucial indicators used in the early identification and management of sepsis in the Intensive Care Unit (ICU) is the measurement of lactate levels in the blood. This article discusses the pivotal role of monitoring lactate levels in the efforts of early sepsis recognition and effective management in the ICU setting.



Sepsis is the body's excessive response to an infection that can result in systemic organ dysfunction. Sepsis is a medical emergency and necessitates immediate recognition and action. One of the key indicators in the evaluation of sepsis is the level of lactate in the blood. Elevated lactate levels can serve as a crucial indication of circulatory and tissue perfusion dysfunction, which are characteristic of sepsis.

The Critical Role of Lactate Levels

1. Early Identification

Measuring lactate levels can aid in identifying sepsis at its early stages. High lactate levels can indicate that the patient is experiencing circulatory and tissue perfusion dysfunction, which is characteristic of sepsis.

2. Evaluation of Therapeutic Response

Monitoring lactate levels periodically can provide information about the extent to which the patient responds to the administered therapy. A decrease in lactate levels can indicate the effectiveness of the intervention.

3. Prognosis Assessment

Studies have shown that early lactate levels can be used as a prognostic factor to assess the severity of sepsis and the potential complications that may arise.

Methods of Lactate Level Measurement

The measurement of lactate levels can be done using arterial or venous blood analysis. Most hospitals and intensive care units have equipment capable of rapidly and accurately measuring lactate levels. What is the practical method for measuring lactate levels in the blood?

The measurement of lactic acid levels, as part of monitoring cases of lactic acidosis, can be easily and practically performed independently using a reliable Point of Care Test (POCT) tool for examining the lactic acid profile in the blood, known as THE EDGE ™ Blood Lactate Monitoring System. This system is applicable not only to individuals with diabetes mellitus and its complications, asthma, sepsis, and chronic obstructive pulmonary disease but also to healthy individuals who wish to monitor their lactic acid profile after exercise. Therefore, THE EDGE ™ Blood Lactate Monitoring System is also suitable for use by athletes and coaches to accurately assess muscle ability, enabling professional athletes to enhance performance in accordance with their targeted expectations. The following are the features and advantages of THE EDGE ™ Blood Lactate Monitoring System:

  1. Wide measurement range: 6 ~ 200 mg/dL (0.7 ~ 22.2 mmol/L)

  2. Measurement time: 45 seconds

  3. Sample volume: 3µL whole blood

    • Utilizing a minimal sample size and employing whole blood cells, THE EDGE ™ Blood Lactate Monitoring System accurately presents the lactic acid profile in blood, thereby minimizing the risk of excessive discomfort during the blood sample collection process.


Monitoring lactate levels plays a key role in the early identification and management of sepsis in the intensive care unit. Elevated lactate levels can provide an indication of sepsis severity, while a decrease in lactate levels can indicate a therapeutic response. Therefore, regular monitoring of lactate levels is crucial in efforts to improve the prognosis and outcomes of patients with sepsis.


  1. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-1377.

  2. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for the management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165-228.

  3. Insert Kit THE EDGE ™ Blood Lactate Monitoring System.
  4. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22(7):707-710.

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